Assassin's Creed

In 2012, bartender Desmond Miles (Nolan North) is kidnapped by agents of Abstergo Industries, the world's largest pharmaceutical conglomerate, and is taken to their headquarters in Rome. Under the supervision of Dr. Warren Vidic (Philip Proctor) and his assistant Lucy Stillman (Kristen Bell), Desmond is forced to enter a machine called the Animus, which can translate his ancestors' genetic memories into a simulated reality. Vidic instructs Desmond to relive the early years of Altaïr Ibn-La'Ahad (Philip Shahbaz), a senior member of the Assassin Brotherhood during the Third Crusade.
In 1191, Altaïr and two fellow Assassins—brothers Malik (Haaz Sleiman) and Kadar Al-Sayf (Jake Eberle)—are sent to Solomon's Temple to retrieve an artifact known as the Apple of Eden from the Brotherhood's sworn enemies, the Knights Templar. Blinded by arrogance, Altaïr botches the mission, resulting in Kadar's death; however, Malik is able to grab the Apple before escaping. Although Altaïr later partially redeems himself by fighting off a Templar attack on the Assassin home base of Masyaf, his mentor and superior, Al Mualim (Peter Renaday), demotes him and orders him to assassinate nine individuals in order to regain his previous position and honour:

Tamir (Ammar Daraiseh), an arms merchant in Damascus selling weapons to both the Crusaders and Saracens.
Garnier de Nablus (Hubert Fielden), the leader of the Knights Hospitalier, who conducts mind-altering experiments on patients at his hospital in Acre.
Talal (Jake Eberle), the leader of a gang of slavers in Jerusalem.
Abu'l Nuquod (Fred Tatasciore), a pompous trader and regent of Damascus stealing money intended to fund the war.
William V, Marquess of Montferrat (Harry Standjofski), Acre's cruel and abusive regent who is forcefully conscripting citizens and hoarding food.
Majd Addin (Richard Cansino; based on Baha ad-Din ibn Shaddad), a tyrant who rules Jerusalem through fear by holding public executions.
Master Sibrand (Arthur Holden), the paranoid leader of the Knights Teutonic, who plans to betray the Crusaders by blocking the ports of Acre.
Jubair al Hakim (Fred Tatasciore), a scholar using his position to seize and destroy all written knowledge in Damascus.
Robert de Sablé (Louis-Philippe Dandenault), the Grand Master of the Templars who has been taking advantage of the Crusade to further his Order's ideological goals.
As Altaïr eliminates each target, he discovers all nine are Templars who had conspired to retrieve the Apple, revealed to be a relic of a long-forgotten civilization said to possess god-like powers. The Templars hoped to use the Apple to conquer the Holy Land in the name of peace, with each member being assigned a specific task to prepare the population for their eventual takeover. As he slowly learns more about the Templars' goals, Altaïr comes to question the nature of Al Mualim's orders while becoming more humble and wise and making amends with Malik. During his assassination attempt on Robert de Sablé, Altaïr is tricked with a decoy: a Templar named Maria Thorpe (Eleanor Noble). Maria reveals that Robert had anticipated the Assassins would come after him and went to negotiate an alliance between the Crusaders and Saracens against them.
Sparing Maria's life, Altaïr confronts Robert in the camp of King Richard I of England (Marcel Jeannin) and exposes his crimes. Unsure of whom to believe, Richard suggests a duel to determine the truth, remarking that God will decide the victor. After Altaïr mortally wounds him, Robert identifies Al Mualim as the final conspirator, revealing that the latter has betrayed both the Assassins and Templars to acquire the Apple. Altaïr returns to Masyaf, where Al Mualim has used the Apple to enthrall the population, as part of his plan to end the Crusade and all human conflict by eradicating free will. With the help of Malik and several Assassins brought for backup, Altaïr storms the citadel and confronts Al Mualim in the gardens, resisting the Apple's powers and killing his mentor. He then tries to destroy the artifact, but instead unlocks a map showing the locations of countless other Pieces of Eden around the world.
In the present, the Assassins launch an unsuccessful attack on the Abstergo facility to rescue Desmond, resulting in most of them being killed. After completing Altaïr's memories, Vidic reveals to Desmond that Abstergo is a front for the modern-day Templars, seeking to find the remaining Pieces of Eden. With Desmond having outlived his usefulness, Vidic's superiors order him killed, but Lucy, who is implied to be an Assassin mole, convinces them to keep him alive for further testing. Desmond is left alone in his room, where he discovers strange drawings written in blood describing an upcoming catastrophic event.