Plot summary
Annie realizes that her experiences with Owen on the "B" pill are unique, causing her to feel close to him. Owen, however, worries that being connected to Annie in his dreams is a symptom of his schizophrenia, causing him to doubt the study. Azumi fears that Annie and Owen's connection is being caused by the GRTA computer and reveals to James that GRTA is depressed because, after Azumi coded her with basic empathy, GRTA began a workplace romance with Dr. Muramoto and is now in grief over his death. At the behest of Azumi and GRTA, James reluctantly calls in his mother, pop psychologist Dr. Greta Mantleray, with whom he has a contentious and difficult relationship, so that she can treat GRTA, whose intelligence and virtual appearance are modeled after Greta. The subjects are given the "C" pill and begin the final phase of the trial.
Credits
Adapted from Wikipedia contributors, Maniac (miniseries). Series, exact episode number and English title matched. Paragraphs formatted; references and illustrations omitted.