Plot summary
The new LMDs are aware of their nature and plan to carry out Ivanov's goal of destroying all Inhumans. Simmons discovers that Mace, Mack, and Fitz are the other new LMDs and overpowers Fitz. Daisy also discovers them and plans, with Simmons, to hack into the Framework remotely to find the others from the inside. Aida kills Radcliffe's body, but lets his consciousness live in the Framework. Daisy overpowers the Mace, Mack, and Coulson LMDs, but they find the May LMD waiting for them at the base entrance, tasked with detonating a large explosive to prevent their escape.
The May LMD instead lets them leave and destroys the base with the LMDs inside. In the Framework, the agents find an altered reality: Daisy is in a relationship with an alive Grant Ward; Coulson is teaching about Inhumans; Hope is alive with Mack; Fitz is rich; Simmons is dead; and May works for Hydra, which has replaced S.H.I.E.L.D. In the real world, Aida is able to sever Ivanov's living head from his crippled body and builds android bodies for his mind to control.
Credits
Adapted from Wikipedia contributors, Agents of S.H.I.E.L.D. season 4. HTML formatting and reference markers removed.