Plot summary
Hoping Radcliffe can help them escape, Daisy returns to Hydra and locates him, but May gives her a new mission on the orders of Fitz and Aida, the latter choosing to go by Ophelia or Madame Hydra. Ward directs Coulson (who can remember some things, thanks to previous tampering with his mind) and Simmons to the Resistance, the remnants of S.H.I.E.L.D. under the command of an Inhuman Mace. Ward, Simmons, and Coulson take a stolen Hydra quinjet to extract Radcliffe. May and Daisy arrest Mack, and May forces him to trick Daisy into confessing her true allegiance.
The others find Radcliffe living in seclusion with Kitsworth, but they cannot leave the Framework due to their real bodies having died. Fitz and Madame Hydra arrive and Radcliffe attempts to appeal to Fitz, though Fitz already knows of the "other world" and that Radcliffe enslaved Aida there. He kills Kitsworth and imprisons Radcliffe, torturing him and Daisy. Regretting his actions, Mack joins the Resistance.
Credits
Adapted from Wikipedia contributors, Agents of S.H.I.E.L.D. season 4. HTML formatting and reference markers removed.