22. World's End

Ivanov takes the Darkhold to an international meeting about S.H.I.E.L.D. and recent events. He proposes to use the book against the Inhumans, which is timed with an attack on the group by an LMD of Daisy, who shoots Talbot in the head, leaving him comatose. In the ensuing fight, S.H.I.E.L.D. is able to retrieve the Darkhold with Reyes' help. In the Framework, Rodriguez is unable to convince Mack to leave, but he returns with her after Hope's code is deleted as a result of Ophelia shutting down the Framework.

Radcliffe is also deleted after accepting that immortality without Kitsworth is worthless. Ophelia comes for the Darkhold and Coulson surprises her by unleashing the Spirit of Vengeance himself, having made a deal to become the Ghost Rider for a short time. He incinerates Ophelia. Reyes, now the Ghost Rider again, takes the Darkhold through a portal. The S.H.I.E.L.D. agents then wait to be arrested by the government, but are instead taken by a mysterious group. Some time later, Coulson finds himself on a space station.