Plot summary
The team argues about the usage of the Centipede serum until May destroys the odium vial. Deke advises Daisy to help unite the team and settle their differences. Under coercion, Robin informs Talbot of a gravitonium deposit in Chicago, to which he commandeers Qovas' ship. Daisy chooses Mack to lead S.H.I.E.L.D. and he coordinates the team as they evacuate as many civilians as possible. Simmons provides Coulson with the Centipede serum, but he refuses to take it and discreetly hides it in Daisy's gauntlets while convincing her to face Talbot alone.
Daisy attempts to appeal to Talbot's patriotism, but Talbot attacks and attempts to absorb her. Discovering the serum, Daisy injects herself with it and uses her enhanced abilities to blast Talbot into space, thus changing the timeline. While rescuing Polly and Robin from Qovas' ship, Fitz is mortally wounded by falling debris, May and Mack staying by his side as he dies. Simmons resolves to find the present version of Fitz, who is in stasis aboard Enoch's ship. After bidding his fellow agents farewell, Coulson is accompanied by May as he leaves S.H.I.E.L.D. to spend his last days in Tahiti.
Credits
Adapted from Wikipedia contributors, Agents of S.H.I.E.L.D. season 5. HTML formatting and reference markers removed.