Plot summary
A year after the death of director Phil Coulson, S.H.I.E.L.D. is rebuilding under the leadership of Alphonso "Mack" Mackenzie. They investigate a series of energy anomalies formed by hostile strangers emerging from portals, one of whom gets trapped inside a wall and partially turns to concrete. In deep space, Agents Daisy Johnson, Jemma Simmons, Piper, and Davis search for Leo Fitz, who was last seen in a cryofreeze chamber on a spaceship with the Chronicom Enoch; they find the spaceship abandoned and the chamber empty.
Simmons learns that the chamber was created on Naro-Atzia, but the others decide to return to Earth. They are attacked by a Confederacy cruiser and, in the rush to escape, Simmons plots a course to Naro-Atzia. Mack and Melinda May recruit Dr. Marcus Benson to help found a S.H.I.E.L.D. academy and provide science support. They find coordinates on the man in concrete, Tinker, which lead them to a museum. The surviving hostiles are there and destroy the building to make way for their leader, Sarge, who looks just like Coulson.
Credits
Adapted from Wikipedia contributors, Agents of S.H.I.E.L.D. season 6. HTML formatting and reference markers removed.