Plot summary
While in Sarge's custody, May is forced to kill a parasite-infected man. Afterwards, he reveals that it was part of the "Shrike" parasites that infect worlds and destroy them on behalf of their creator, and that he intends to stop them once and for all. May eventually turns the tables on Sarge and brings him back to base, all while experiencing memories of Coulson. Daisy's team is captured by Chronicoms led by Atarah, Enoch's former superior. After their home world was destroyed by a mysterious plague, they took the Confederacy's ships to defend themselves and kidnapped Fitz to unlock the secret to time travel.
With Enoch betraying them and no other choice, Simmons surrenders to the Chronicoms in order to reunite with Fitz and so Daisy and her team can return to Earth. Mack and Benson comfort Yo-Yo, who is still affected by Keller's death. While performing the autopsy, Benson learns that the parasite and the knife used to kill it are composed of crystals similar to the Monoliths the S.H.I.E.L.D. agents have encountered in the past. Enoch reunites with Fitz and gets him up to speed on what has happened before gassing him, betraying him as well.
Credits
Adapted from Wikipedia contributors, Agents of S.H.I.E.L.D. season 6. HTML formatting and reference markers removed.