Plot summary
Fitz and Simmons tell the field team what happened to May, but communications are shut off and the Lighthouse is put on lockdown. Malachi and the Chronicoms attack, using Fitz and Simmons' knowledge to anticipate their every move. Barricaded in a room with Framework tech, Fitz and Simmons prepare to sacrifice themselves to destroy it so the Chronicoms cannot use it, but a disguised Enoch saves them and proposes a plan. With the Zephyr disabled, Mack has Deke fly the Quinjet to them, but Yo-Yo is infected by a Shrike.
In between realms, where life and death do not matter, May destroys three hooded figures before they can let Izel's kind through. Izel herself appears and overpowers her to establish the connection. Daisy, Mack, and Yo-Yo battle Pachakutiq, but are no match for him. Izel reappears, but May stabs her from behind, killing her and freeing Yo-Yo. Mack kills Pachakutiq, closing the portal. As May slowly dies, Simmons appears with a team and an upgraded Zephyr, putting May in a stasis pod. Everyone evacuates before the Chronicoms destroy the temple and Monoliths.
Fitz remotely sends them to safety with an upgraded jump-drive, landing them several decades in the past above Manhattan. Simmons explains that, because the Chronicoms know everything about S.H.I.E.L.D., they will need their own expert to help them fight back, revealing a Chronicom tech-enhanced Coulson Life Model Decoy (LMD).
Credits
Adapted from Wikipedia contributors, Agents of S.H.I.E.L.D. season 6. HTML formatting and reference markers removed.