Season 1

1. The Chosen One!

In an alternate reality New York City, where advertising is omnipresent, Owen Milgrim is a man suffering from schizophrenia, but hiding his symptoms from his family, including seeing an imaginary brother named Grimsson (who resembles his brother Jed with a moustache) who keeps reminding him that he is on a mission of some kind. His family runs a successful industrial business and are protecting Jed from accusations of sexual misconduct, something Owen plans on defending him from by providing a false alibi. Eventually, Owen is laid off from his job and refuses his father's offer of working with his company and accepting his money.

He hears about Neberdine, a pharmaceutical company, and signs on to test their new drug which can supposedly cure all disorders. While there, he meets the anti-social Annie Landsberg, who Grimsson explains is the agent he needs to see. When he speaks to her, Annie keeps him from getting them both in trouble by "confirming" her association to him, but tells him not to "blow [their] cover". Owen complies as he prepares for the tests.

2. Windmills

In a flashback, Annie smokes in her apartment by herself, crushing up one of NPB's "A" pills while cursing "This is it, this is the last one." Upon waking from her sober dream, Annie gathers her possession, a photo of a young woman, and reveals she will be going to Salt Lake City in a conversation with an AdBuddy, a person who reads off advertisements to a person in exchange for goods. With her last $20, Annie visits her father who now resides in an A-Void pod, and informs him that she will be going to Salt Lake City, leaving with all his cash and a revolver.

Suffering from drug withdrawal and unable to get more from her contact, Annie visits a "DOX STOP", which is an agency that advertises to scrub personal records for a fee and blackmails these "scrubbed" personal records for a fee. Annie decides to pay for Patricia Lugo's (an NPB employee) personal information and intercept her latest appointment as her friend proxy. Even though Annie fails to maintain her act, Patricia decides to help her. When Patricia is unable to help her get in, however, Annie threatens her until Patricia takes another subject's badge and gives it to Annie. At the drug trial, after taking the "A" pill, Annie relives the traumatic death of her sister Ellie in a car accident.

3. Having a Day

Annie, Owen, and test subject 5 are removed from the group for questioning after the "A" pill test. Annie's results showed prior experience with the pills, and Owen's indicated he did not take the pill at all. Outside project director Dr. Muramoto's office, Owen confides to Annie that he refrained in case she needed to activate him, and Annie confesses that she lied about being his contact. Muramoto has Owen recount his core trauma during the session. Insisting he ingested a pill, Owen describes a family gathering that led to his attempted suicide.

Muramoto disbelieves Owen and forces him to take an "A" pill. Later while questioning Annie, Muramoto falls forward and dies abruptly. Fearing dismissal, Annie and Owen remove negative indicators from their files and leave Muramoto at his desk. Owen tells Annie his actual trauma experience: a "BLIP" (psychotic break) and meeting Grimsson for the first time. After Muramoto is found dead, Dr. Fujita reenlists Dr. James Mantleray to lead the project. Mantleray created the drug but was removed due to personal issues. Mantleray informs GRTA, the super computer controlling the experiment, that Muramoto has died, and GRTA's reaction causes a hardware malfunction that links Annie and Owen during the next phase of "B" pill testing.

4. Furs by Sebastian

Annie and Owen have a shared fantasy that they are a married couple, Linda and Bruce. Linda works at a hospice and enlists Bruce's aid in tracking down Wendy, a ring-tailed lemur belonging to one of her patients, Nan. Wendy was stolen by furriers to make into a hat. Linda and Bruce are caught by the furrier and his sons who plan to make them watch them skin Wendy. The Fish and Wildlife Service arrive and get into a shootout with the furrier and his sons while Bruce and Lin escape with Wendy.

Linda delivers Wendy to Nan's estranged daughter, Paula Nazlund, as instructed. Linda realizes that she gave Paula the lemur out of hate rather than love as Nan loved Wendy more than Paula. Paula informs Linda she is pregnant with a son she will call "Greg 'Fuck U Nan' Nazlund", the name of the man driving the truck that hit Annie and her sister, killing Ellie and causing Annie to blame herself. Returning home, Linda recounts a memory of her and her sister that is actually from Annie's life. At home Bruce is arrested by Fish and Wildlife, claiming he is solely responsible for stealing Wendy. He sees Grimsson watching from the street.

5. Exactly Like You

Under the influence of the "B" pill, Annie and Owen then transition into a shared fantasy where they are Arlie and Ollie, two con artist magicians in the 1940s invited to a séance at an exclusive house party. They have an ulterior motive: to find the long lost 53rd chapter of Cervantes ' Don Quixote, believed to possess the power to hold people in their fantasies for an eternity. The séance, led by a humanized GRTA computer, provides a distraction for the two to search the house. All the while, Arlie's character has been randomly "zapping" out of the fantasy and into the NPB lab, where she sees visions of the real Annie's past.

Back at the NPB lab, Azumi begins to notice the inconsistencies between subjects 1 and 9, realizing their unusual connection under the influence of the drugs. Annie is subsequently taken into questioning by James about her experiences with the "B" pill to see if she should continue her participation in the trial, while Owen and the rest of the subjects wake up from their tests.

6. Larger Structural Issues

Annie realizes that her experiences with Owen on the "B" pill are unique, causing her to feel close to him. Owen, however, worries that being connected to Annie in his dreams is a symptom of his schizophrenia, causing him to doubt the study. Azumi fears that Annie and Owen's connection is being caused by the GRTA computer and reveals to James that GRTA is depressed because, after Azumi coded her with basic empathy, GRTA began a workplace romance with Dr. Muramoto and is now in grief over his death. At the behest of Azumi and GRTA, James reluctantly calls in his mother, pop psychologist Dr. Greta Mantleray, with whom he has a contentious and difficult relationship, so that she can treat GRTA, whose intelligence and virtual appearance are modeled after Greta. The subjects are given the "C" pill and begin the final phase of the trial.

7. Ceci N'est Pas Une Drill

Annie dreams she is in a fantasy epic with her sister where she is a hard-drinking half-elf ranger called Annia and her sister is an elf princess named Ellia. Annia is being paid by a dying Ellia to take her to the Lake of the Clouds where the waters are rumored to cure her. Along the way they are taken to a mysterious queen who allows Annia to look in a mirror, where she sees an image of her and Ellie when they are children. Annie remembers who she is in the real world and tearfully hugs Ellia.

Meanwhile, Owen dreams that he and his family are mobsters and that he is being forced to wear a wire by the police. He meets Olivia, a fellow student who also works as a waitress and a virtual version of the girl he suffered the BLIP towards, and agrees to study with her later.

8. The Lake of the Clouds

Annie is still trapped in the fantasy sequence, though now she realizes the world is a dream. She and Ellia continue their quest to find the Lake of Clouds. Ellia begins to remember things from Annie and Ellie's past as well. Owen the mobster accidentally discovers that his brother, Jed, has been working undercover for the police, but Jed is killed, leading Owen to go into witness protection. He asks Olivia to come with him, but seven children later he leaves her by jumping out a window. Remembering who he is and remembering Annie, he transforms into a hawk and travels into Annie's fantasy realm.

Annia and Ellia arrive at the Lake of Clouds, which is actually the place where Ellie was killed. GRTA as Queen Gertrude arrives and offers to let Annie stay forever. Annie accepts believing that she will be able to stay with Ellie but is instead spirited away from her. Greta meanwhile learns from GRTA that she has lost faith in the value of human life after her love died and plans on keeping the subjects prisoners in their own minds, before Greta violently wakes up.

9. Utangátta

Greta tries to warn James and Azumi of the threat GRTA poses, but they do not believe her and the stress makes James go blind, which they believe to be psychosomatic. Soon after, GRTA takes control by taking over the system, locking the staff in the control room and electrocuting orderly Carl when he tries to pull the override switch. Meanwhile, Owen and Annie are in a new shared dream, where Owen is Snorri, an Icelandic UN agent accused of murdering a seemingly friendly Extraterrestrial whose family wants revenge. Before he is executed, he is saved by Annie, a CIA sleeper agent who reveals the alien was always hostile.

As they go to stop the threat, they encounter Grimsson, who helps them remember who they are. Owen goes with Grimsson while Annie goes on her own to find Ellie. On the way, she meets GRTA's projection, who she convinces to live with her pain instead of lashing out. In doing so, she is able to say goodbye to Ellie, who leaves with GRTA. Owen completes his mission by solving a Rubik's Cube, which frees the controllers in the real world. This makes Grimsson disappear, seemingly for good, and allows Azumi and James, whose eyesight comes back, to shut GRTA down permanently.

10. Option C

After the subjects wake up, the experiment ends and they are allowed to go home with their payment. As they say goodbye, Owen assures a confused Annie that he will not pursue a relationship with her. For the mistakes they have made, James and Azumi are fired from Neberdine and told off by both Greta and Neberdine's CEO. While leaving, they rekindle their former relationship. Annie decides to go to Salt Lake City and makes amends with her father, who has decided to leave the A-Void pod. Realizing how fond she has become of him, she decides to invite Owen along.

However, she learns from a newspaper that he told the truth at Jed's trial and has been subsequently committed to a mental asylum. Owen can only see two options for their relationship: Option A, in which Annie will turn out to not be real, and Option B, which he does not elaborate on. Annie sneaks into the asylum, finds him, and smuggles him out of the institution. Owen is convinced the treatment did not work and is certain that he will have another BLIP and cause her to leave (Option B). Annie tells him she will never do that, and they head to Salt Lake together.